When her husband is hospitalized after a car accident, EMT Karen decides to rent out their spare rooms online. All goes well until Miranda moves in. Miranda quickly infiltrates all areas of Karen's life. When one of Karen's renters is found murdered, Karen becomes convinced Miranda was involved but has no idea that kicking her psychotic guest out will send Miranda into a murderous rage.

The lives of a nightclub owner, a crime boss, a stripper, a bartender, two hitmen, a prostitute and a psychic take a turn for the worse when they are trapped in an escaped mental patient's sinister path of madness and destruction.